Researchers at Nationwide Children’s Hospital have shown that a gene delivery strategy that produces follistatin — a naturally occurring protein that inhibits myostatin, a growth factor expressed specifically in skeletal muscle — directly to the quadriceps of non-human primates results in long-term gene expression with muscle enhancing effects, including larger muscles with greater strength. Jerry Mendell, MD, principal investigator in the Center for Gene Therapy at Nationwide Children’s added, "These findings serve as the basis for testing in patients and give us confidence in moving forward with our translational program of follistatin to enhance muscle mass. The potential use of this strategy for muscle strengthening has important implications for patients with muscle diseases including Duchenne muscular dystrophy — the most common form of muscular dystrophy — as well as for the planned first clinical trial for inclusion body myositis. It also may be applicable to other forms of muscular dystrophy, such as facioscapulohumeral muscular dystrophy, in which gene replacement or other types of gene manipulation are not feasible because of the absence of a specific gene defect. Follistatin Gene Delivery Enhances Muscle Growth and Strength in Nonhuman Primates . New research in these primates suggests that a gene delivery strategy that produces follistatin can improve muscle mass and function. read more
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