In advanced stages of cancer, particularly in pancreatic and lung cancers, patients frequently suffer from a wasting syndrome known as cancer cachexia. This process seems to be caused by signals from the tumor itself, which radically direct metabolic processes in the body towards degradation and cause a state of chronic inflammation in the body. In particular, they searched for a molecule called RIP140, previously identified by Herzig as a regulator suppressing fat breakdown in the livers of healthy mice. Indeed, the investigators found a high activity of RIP140 in the cancerous mice and, accordingly, signs of fatty liver in these animals. When Herzig specifically switched off this molecule in the liver cells of tumor-bearing mice, the lipid balance of the liver normalized within a few days. read more
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